GameTrailers has a great walkthrough, here is the first entry:
To beat No More Heroes 2, you must work your way up through the ranks to become the #1 assassin. Your first battle in the game is against the 51st ranked assassin, but thankfully you do not have to kill all 50 of the remaining assassins standing between you and first! Read below for strategies on beating the assassins you do have to defeat in order to win the game.
No. 51: Skelter Helter
When you first have control of Travis Touchdown, you’ll be facing an albino enemy, Skelter Helter, the brother of some poor fool you slaughtered in the first No More Heroes. This guy is no pushover. The game [...]